The Sinclair Method
Yes — often very well. Binge drinking is typically reward-driven, which is exactly the pattern naltrexone targets best.
Dr Seth Rankin
MBChB MRCGP, GMC 4467397
19 April 2026
5 min read

Binge drinking — drinking heavily on specific occasions rather than every day — is often the pattern people are most embarrassed about and most hopeful for change in. It tends to be highly reward-driven: you drink because the first few feel great, and then the brain pulls you toward the next round. This is precisely the pattern the Sinclair Method targets.
The mechanism of pharmacological extinction targets the brain's opioid reward system. The bigger the reward signal, the more naltrexone has to block, and the more dramatic the unlearning per drinking occasion. Binge drinkers typically experience large reward signals and fewer drinking occasions, which means each occasion does more extinction work.
In our experience, binge drinkers often see meaningful reduction faster than steady daily drinkers — sometimes within the first 4-6 weeks rather than the more typical 8-12. The sessions either get shorter, less heavy, or both.
Take one tablet of naltrexone one hour before you start drinking. That's it. The protocol is the same as for any other drinking pattern. The challenge is timing — binges are often planned occasions (a Friday night out, a wedding, a barbecue) and the discipline is taking the tablet during the day or evening before things start.
Set an alarm for one hour before the planned start of the night
Keep tablets in your wallet or jacket pocket so they're with you when plans change
If a binge starts unexpectedly and you don't have a tablet on you, take one as soon as you can — partial coverage is still better than none
Don't compensate with multiple tablets per session — one is the right dose
Three patterns we see commonly with binge drinkers on TSM:
Number of drinks per session falls. You stop after four pints instead of seven, or after a bottle of wine instead of two.
The point of intoxication shifts. You feel pleasantly buzzed but don't get to the loud, sloppy stage.
The craving for the 'next round' weakens. You're more likely to switch to soft drinks midway through, or to leave when you'd previously have stayed for one more.
Some patients find their bingeing stops entirely, replaced by occasional moderate drinking. Others reduce the frequency rather than the intensity (one binge a month instead of two). Most see some combination of both.
If your bingeing is driven primarily by social context (everyone else drinking, drinking culture at work events) rather than by craving, TSM helps less. The medication can quieten the urge but won't change the social dynamic. We'd encourage you to think about both layers — the medication for the biology, and some thinking work for the context.
If you're not sure whether the method fits your pattern, our 'Is the Sinclair Method right for me?' decision guide walks through five questions that often clarify it.
Clinically reviewed
Dr Seth Rankin · MBChB MRCGP, GMC 4467397
Last reviewed on 19 April 2026
Next review due 19 April 2027
Reviewed by the LoveMyLife clinical team
More from our Sinclair Method articles.
3 services

A short, plain-English explanation of how naltrexone, taken before drinking, changes a patient's relationsh...

Most patients see noticeable change by week 4-6. Full extinction takes 3-4 months. Here's the honest timeline.

A day-by-day guide to the first two weeks — titration, side effects, what changes and what doesn't yet.
Different parts of the story live on different pages. Open whichever is most useful to you.
6 services

The main service page — overview, pricing summary, and how our four tiers work.

Four tiers from £99, all-inclusive. Compare each tier side by side with a feature ticklist.

Pharmacological extinction, explained clearly — how naltrexone works on the brain's reward system.

Five honest questions to work out whether the Sinclair Method is the right approach for you.

Thirty-plus questions answered in plain English, grouped by theme.

Side by side with the other UK Sinclair Method providers — what each of us offers, honestly.
The consultation form takes 15-20 minutes. We confirm your tier and next steps within 24 hours.