Opening mid-June at Westfield London. Register your interest to be first to know. Email us

The Sinclair Method

A medical programme for people who want to drink less. Naltrexone takes the reward out of alcohol over three to four months, so the urge softens and the habit loosens with it. It works alongside your own effort, not instead of it.

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A medical approach that works alongside your effort

The Sinclair Method uses a well-established medicine called naltrexone, taken one hour before you plan to drink. Over three to four months, it gently unwinds the brain's reward response to alcohol. The urge quiets. Drinking becomes something you can put down. For most patients, the change is gradual but real and durable.

It is not a willpower replacement. It is a willpower assistant. Think of it the way many people now think about GLP-1 medicines for weight: the medicine does the hard pharmacological work of turning the volume down on a craving, and the person does the life work of deciding what to do with that quieter moment. Neither can do it alone.

Like every medicine, it suits some people better than others. About three in four people who stick with it see a meaningful reduction in their drinking. The one in four or so who do not often have a different pattern of drinking (habitual or social rather than reward-driven), or a genetic variation in the opioid receptor, or a bigger underlying picture (unresolved depression, trauma, anxiety) that the medicine on its own cannot reach. We talk about this openly at the start. We never promise a cure, and we respect every person's choice — whether that is reduction, abstinence, AA, NA or combinations of all of these. Many people use naltrexone alongside AA and that is a valid path.

How it works at LoveMyLife

You choose your level of support: a form-reviewed prescription, a doctor consultation, or our full nurse-led 90-day programme.

Your assessment

A form or a doctor consultation, you choose. We confirm TSM suits you, run any bloods you need, and explain the titration plan.

Your first dose

You start at a quarter tablet to check tolerance, then step up to a full tablet over 2-3 weeks. Take it one hour before you plan to drink.

Your programme

Three to four months of support — from an online check-in at its lightest to full nurse-led coaching at its fullest. Your choice.

Begin your consultation

Everything you might want to know

Eight short reads on how the method works, what we offer, and what to do if it isn't right for you. Skim what's relevant.

Frequently asked questions

Why LoveMyLife for the Sinclair Method

Most UK Sinclair Method services are entirely online, coaching-led, or both. LoveMyLife is a private medical clinic that runs TSM as an integrated medical programme.

A real clinic you can walk into, at Westfield London (opening June 2026).
GMC-registered doctors, not just coaches or an app.
Registered UK nurses trained specifically in TSM, operating under formal Patient Group Direction.
Our own GPhC-registered pharmacy dispensing naltrexone and nalmefene at £99/pack, direct to your door or collected in clinic.
Our own blood testing lab (London Medical Laboratory) for liver function tests at £49 — or bring your own NHS LFT for free.
Four tiers from £99 so the programme fits your life, not the other way round.
An optional Ongoing subscription for post-programme support, monthly rolling, cancel any time.
Honest about what the medicine can and cannot do. No fear-based messaging. No hype.